What's New in Immunopathogenesis of HIV Dugast, Harvard Medical School,Hecht, UCSF Medical School, Bunnick, from the Netherlands, and Klatt et al, fr

What's New in Immunopathogenesis of HIV Dugast, Harvard Medical School,Hecht, UCSF Medical School, Bunnick, from the Netherlands, and Klatt et al, from NIH, NIAID

One of the reasons why there has been little progress in the development of a vaccine or other immune based therapies is because there has been a weak understanding of the Immunopathogenesis of HIV. In the past there has been a focus on viral load and CD 4 counts. While these markers are still important,emphasis on immune activation is becoming more and more important. It is now very obvious from these researchers, that until the ongoing immune activation because of HIV is stopped,no particular treatment or prevention will completely succeed.

The process starts and is continuing with microbial translocation of the gut From there the lamina propria of the GI tract is broken down by the HIV invasion, and microbial organisms penetrate the lumen of the gut and the circulation, The best marker of this going on is lipopolysaccharide or LPS. If LPS is high, immune activation is still going on. A second marker to follow is activated CD 4 cells, and a third marker of this process is % lymphocytes.

The process continues with the activated T lymphocytes, depleting the NK cells which previously was thought to be the most important cell in the immune system in protecting the immune system. But people are turning towards the stem cell as the cell that has possibilities of stopping this immune activation system Blue green algae tested properly with clinical trials that we are proposing and backing these trials up with immunological monitoring will to find the mechanism as to how Blue green algae enhancer of bone marrow stem cells might work.

If we can find out that mechanism, then we maybe able to use Blue green algae during many stages in the history of HIV infection. To do this the foundation needs donations to set up these clinical trials and laboratory experiments. To be a part of the process that might give a solution to the HIV pandemic, please donate on line to one of our web sites, www.schickfoundaton.org or www.schickresearch.com Alternatively you could send a check, or money order, to The Peter Schick Foundation, 1223,Wilshire Blvd. #1007, Santa Monica California, 90403. If you have any questions you can call 1-310-394-7989. I will be happy to answer any questions you might have.

Peter Schick

Chairman of the Board and Founder of the Peter Schick Foundaton